White matter hyperintensity transcriptomics in Alzheimer's disease

🔗📕 Paper: Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer’s disease

Abbreviations

  • AD: Alzheimer’s disease
  • WM: White matter
  • WMH: White matter hyperintensity

Identifying low- and high-WMH burden cases for bulk white matter tissue and microvessel RNA sequencing

Adapted from Figure 1 in Malla, Bryant, et al. (2025): Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer’s disease.

Alterations in brain vasculature pathways are underlying features of AD WM

Adapted from Figures 2-3 in Malla, Bryant, et al. (2025): Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer’s disease.

Analysis of AD donors with high-WMH burden reveals distinct, regional upregulation of genes associated with immune function

Adapted from Figure 5 in Malla, Bryant, et al. (2025): Molecular profiling of frontal and occipital subcortical white matter hyperintensities in Alzheimer’s disease.