Homotopic functional connectivity

🔗📕 Preprint: Mapping functional, structural, and transcriptomic correlates of homotopic connectivity

‘Homotopic’ refers to the homologous left and right hemisphere versions of a given brain region. In other words, homotopic functional connectivity (FC) refers to the statistical dependency in resting-state brain activity, indexed here using BOLD fMRI, between the left and right hemispheres for a given brain region.

tl;dr

For a ~10-minute overview on this topic and project, you might want to check out the recording from my presentation at the Organization for Human Brain Mapping (OHBM) 2025 meeting in Brisbane, Australia, either on YouTube here or below.



Homotopic functional connectivity varies along a fundamental axis of cortical organization

Figure 1 from Bryant, Shine & Fulcher (2025): Mapping functional, structural, and transcriptomic correlates of homotopic connectivity.

Spatial variation in homotopic functional connectivity is preserved across neuropsychiatric disorders

Figure 2 from Bryant, Shine & Fulcher (2025): Mapping functional, structural, and transcriptomic correlates of homotopic connectivity.

Homotopic connectivity is linked to broader resting-state functional network topology

Figure 3 from Bryant, Shine & Fulcher (2025): Mapping functional, structural, and transcriptomic correlates of homotopic connectivity.
Figure 3 from Bryant, Shine & Fulcher (2025): Mapping functional, structural, and transcriptomic correlates of homotopic connectivity.